中美科学家利用酶对抗艾滋癌症
文章来源:未知 文章作者:enread 发布时间:2018-04-03 03:12 字体: [世界杯开户 ]  进入论坛
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American and Chinese scientists have identified how a multi-functional enzyme1 works to fight diseases including HIV infection and autoimmune disorders2.
 
来自美国和中国的科学家发现一种多功能酶,可以对抗包括艾滋病感染和自体免疫失调在内的疾病。
 
The study, published on Monday in the journal Proceedings3 of the National Academy of Sciences, has detailed4 how the enzyme called SAMHD1 managed to inhibit5 proteins that stimulate6 the immune response in human and mouse cells, thus opening up the possibility of finding ways to turn this activity on and off and making way for new therapeutic7 approaches for hard-to-treat diseases.
 
The paper's senior author Wu Li, a professor in Ohio State University's Center for Retrovirus Research, and colleagues from China's Wuhan University, have illuminated8 the way in which SAMHD1 act as a neutralizer9 of potentially harmful responses during viral infection.
 
The researchers said that lacking this enzyme due to SAMHD1 gene10 mutations can activate11 the human immune system and increase inflammation.
 
"SAMHD1 is responsible for balanced regulation of the immune response, but it also could limit HIV or other viral infections and alter the progression and treatment of certain cancers," Wu told Xinhua. "We need good immune responses, obviously, but we don't want overwhelming immune activation12."
 
Wu said the enzyme could break down a DNA13 building block in our cells - to act as "molecular14 scissors."
 
"Too much of this building block due to SAMHD1 deficiency caused by genetic15 mutations can lead to autoimmune diseases and help cancerous tumors grow. If we can find a way to cut off or reduce the supply, the disease might not be viable16, like a car without gas."
 
"Because inflammatory pathways influence nearly all diseases in humans and animals, including HIV infection and cancers, identification of SAMHD1 as an inhibitor of immunity17 may have far-reaching implications in biomedical research," he said.


点击收听单词发音  

1 enzyme     
n.酵素,酶
参考例句:
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
2 disorders     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
参考例句:
  • Reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
3 proceedings     
n.进程,过程,议程;诉讼(程序);公报
参考例句:
  • He was released on bail pending committal proceedings. 他交保获释正在候审。
  • to initiate legal proceedings against sb 对某人提起诉讼
4 detailed     
adj.详细的,详尽的,极注意细节的,完全的
参考例句:
  • He had made a detailed study of the terrain.他对地形作了缜密的研究。
  • A detailed list of our publications is available on request.我们的出版物有一份详细的目录备索。
5 inhibit     
vt.阻止,妨碍,抑制
参考例句:
  • Don't let ego and greed inhibit clear thinking and hard work.不要让自我和贪婪妨碍清晰的思维和刻苦的工作。
  • They passed a law to inhibit people from parking in the street.他们通过一项法令以阻止人们在街上停车。
6 stimulate     
vt.刺激,使兴奋;激励,使…振奋
参考例句:
  • Your encouragement will stimulate me to further efforts.你的鼓励会激发我进一步努力。
  • Success will stimulate the people for fresh efforts.成功能鼓舞人们去作新的努力。
7 therapeutic     
adj.治疗的,起治疗作用的;对身心健康有益的
参考例句:
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
8 illuminated     
adj.被照明的;受启迪的
参考例句:
  • Floodlights illuminated the stadium. 泛光灯照亮了体育场。
  • the illuminated city at night 夜幕中万家灯火的城市
9 neutralizer     
n.中和剂,中和器
参考例句:
  • Feasibility of ferroelectric cathode used for neutralizer is proposed. 提出铁电阴极用于小功率电推进中和器的可能性。 来自互联网
  • Heavy Energy Neutralizer II is now better than its best T1 counterpart. 重毁II的性能现在比它们T1的最好型号要高。 来自互联网
10 gene     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
11 activate     
vt.使活动起来,使开始起作用
参考例句:
  • We must activate the youth to study.我们要激励青年去学习。
  • These push buttons can activate the elevator.这些按钮能启动电梯。
12 activation     
n. 激活,催化作用
参考例句:
  • A computer controls the activation of an air bag.电脑控制着气囊的启动。
13 DNA     
(缩)deoxyribonucleic acid 脱氧核糖核酸
参考例句:
  • DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
14 molecular     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
15 genetic     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
16 viable     
adj.可行的,切实可行的,能活下去的
参考例句:
  • The scheme is economically viable.这个计划从经济效益来看是可行的。
  • The economy of the country is not viable.这个国家经济是难以维持的。
17 immunity     
n.优惠;免除;豁免,豁免权
参考例句:
  • The law gives public schools immunity from taxation.法律免除公立学校的纳税义务。
  • He claims diplomatic immunity to avoid being arrested.他要求外交豁免以便避免被捕。
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TAG标签: HIV immune enzyme
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